Super Eagles Nigerian came back to revenge a home defeat to Guinea-Bissau, recording a 1-0 win against same opposition on Monday.
The Djurtus claimed a shock win last Friday when they recorded a 1-0 victory over the Super Eagles in Abuja.
However, a first-half penalty from Moses Simon was enough for Jose Peseiro’s men to win the reverse fixture.
With the result, Nigeria return back to the top of Group A with nine points with two more points than second placed Guinea-Bissau.
The slim victory also ended a four-match losing streak for the Nigerians who have won the AFCON three times.
The third place is occupied by Sierra Leone with five points, while Sao Tome & Principe sit at the bottom of the group with just one point.